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    原作者: Bryan Hayes, 江利冰 翻譯, 發布日期:2015-12-07

    Title: Adverse Effects of Combined Lipid Emulsion + VA-ECMO in Poisoned Patients
    Author: Bryan Hayes
    作者:Bryan Hayes
    翻譯:江利冰 校對:肖鋒

    A new review summarized published adverse effects when IV lipid emulsion is used along with venous-arterial extracorporeal membrane oxygenation (VA-ECMO) in patients with cardiotoxic drug poisoning.
    Not surprisingly, running fat through the ECMO circuit can cause some issues. Here's what's been published:
    • cracking of stopcocks
    • 活塞的破裂
    • fat emulsion agglutination
    • 脂肪乳劑的凝集
    • clogging and associated malfunction of the membrane oxygenator
    • 堵塞以及相關的膜氧合器的功能障礙
    • increased blood clot formation in the circuit
    • 環路中血栓形成增加

    It's unclear how these findings should change management if using both treatment modalities, but at the very least, be aware that fat depostion in the VA-ECMO circuits and increased blood clot formation can occur.
    Lee HM, et al. What are the adverse effects associated with the combined use of intravenous lipid emulsion and extracorporeal membrane oxygenation in the poisoned patient? Clin Toxicol. 2015 Jan 29. [Epub ahead of print, PMID 25634667]