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    蓖麻毒素(美國國會大廈4月6日事件的啟示)
    原作者: Fermin Barrueto,肖鋒譯 文章來源: 《中華急診醫學雜志》編輯部 發布日期:2013-04-25

    Title: Ricin - of course
    題目:蓖麻毒素(美國國會大廈4月6日事件的啟示)
    Author 作者: Fermin Barrueto

    On 4/16/2013, the United States Capitol Police (USCP) was notified by the Senate mail handling facility that it received an envelope containing a white granular substance. The envelope was immediately quarantined by the facility's personnel and USCP HAZMAT responded to the scene. Preliminary tests indicate the substance found was Ricin.
    2013年4月16日,美國參議院郵件處理機構告匯美國國會大廈警察(USCP),他們收到一個信封,里面有白色顆粒狀物質。設施人員將信封立即隔離,USCP危險品控制局馬上到了現場。初步測試表明,該物質是蓖麻毒素。
    A few notes about ricin seems appropriate:
    對蓖麻毒素的認識有如下幾點:
    Easy to make from castor bean though heat labile
    雖然熱不穩定,容易從蓖麻子豆中提取

    No antidote, though Fab like digibind is in development
    沒有解藥,雖然與地高辛特異性抗體(digibind)類式的解藥(FAB)正在開發中

    Granule size of the grain of sand can kill
    一粒沙子的顆粒就可致死

    Inhalation, IM, IV all effective
    吸入,肌注,靜注有同樣效果

    After immediate exposure likely no symptoms
    接觸后可能不會馬上出現癥狀

    Vomiting and diarrhea initially, acute lung injury and death in 3-5 days
    最初會出現嘔吐和腹瀉,在3-5天內出現急性肺損傷以至死亡

    Reference 參考文獻:
    CDC website: http://www.bt.cdc.gov/agent/ricin

    文章來源:《中華急診醫學雜志》編輯部

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